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Haematologica, Vol 91, Issue 12, 1689-1692
Copyright © 2006 by Ferrata Storti Foundation

Comparative Study

Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia

W Barcellini, S Capalbo, RM Agostinelli, FR Mauro, A Ambrosetti, R Calori, A Cortelezzi, L Laurenti, EM Pogliani, P Pedotti, V Liso, G Girelli, F Mandelli, A Zanella, and

Department of Haematology, Padiglione Granelli, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via F. Sforza 35 20122 Milan, Italy. wbarcel@policlinico.mi.it

The aim of this multicenter GIMEMA study was to correlate autoimmune complications (AIC) in B-cell chronic lymphocytic leukemia (B-CLL) with stage and therapy. Autoimmune hemolytic anemia (129/194 cases) and autoimmune thrombocytopenia (35/194 cases) were typically present in advanced and multi-treated disease. Age over the median, stage C and first and second line therapy were identified as independent risk factors by multivariate analysis. In contrast, non-hematologic AIC (30/194 cases) and the presence of serological markers of autoimmunity were mostly observed in early B-CLL, suggesting different pathogenic mechanisms underlying hematologic and non-hematologic autoimmune phenomena in B-CLL.


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