Haematologica
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Haematologica, Vol 91, Issue 12, 1710-1711
Copyright © 2006 by Ferrata Storti Foundation

Letter

Constitutive activation of NF-kappa B is not sufficient to disturb normal steady-state hematopoiesis

H Schepers, BJ Eggen, JJ Schuringa, and E Vellenga

Since nuclear factor-kappaB (NF-kappaB) is frequently activated in acute myeloid leukemia, we questioned whether active NF-kappaB can affect the cellular properties of cord blood CD34+ cells. The results demonstrated that NF-kappaB activation did not influence growth or differentiation properties of these cells. Furthermore, NF-kappaB activation was not sufficient to induce changes in stem- and progenitor cell numbers.


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