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Haematologica, Vol 91, Issue 12_Suppl, ECR57-ECR57
Copyright © 2006 by Ferrata Storti Foundation

Journal Article

MPL W515 and JAK2 V617 mutation analysis in patients with refractory anemia with ringed sideroblasts and an elevated platelet count

DP Steensma, JS Caudill, A Pardanani, RF McClure, TL Lasho, and A Tefferi

Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Steensma.david@mayo.edu

Discovery of a constitutively activating point mutation of the Janus kinase 2 (JAK2) receptor-associated tyrosine kinase in patients with polycythemia vera (PV) and other BCR/ABL-negative myeloproliferative disorders prompted many groups around the world to examine diverse subsets of patients with myeloid diseases for the prevalence of the JAK2 V617F mutation and its clinical and pathological associations.


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