Haematologica
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Haematologica, Vol 91, Issue 12_Suppl, ECR58-ECR58
Copyright © 2006 by Ferrata Storti Foundation

Journal Article

Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response

B Cassinat, I Guillemot, C Molucon-Chabrot, F Zassadowski, P Fenaux, O Tournilhac, and C Chomienne

Unite de Biologie Cellulaire, Hopital Saint-Louis, 1 avenue Claude Vellefaux, 75010 Paris, France. bruno.cassinat@sls.aphp.fr

Rare cases of acute promyelocytic leukemia (APL) are associated with a t(11;17) translocation and a PLZF-RARalpha fusion transcript. Because of molecular specificities of the fusion protein, ATRA efficiency is often reduced in these cases. We present herein the case of an 83-year old patient which has been successfully treated by ATRA and Daunorubicin. The described quantitative RT-PCR method allowed successful monitoring and confirmation of the molecular response.




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Copyright © 2006 by the Ferrata Storti Foundation.