Haematologica
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Haematologica, Vol 91, Issue 2, 268-269
Copyright © 2006 by Ferrata Storti Foundation


Letter

The involvement of cellular proliferation status in the expression of the human proto-oncogene DEK

M Ageberg, U Gullberg, and A Lindmark

The role of the DEK protein, involved in the leukemia-associated fusion protein DEK-CAN, is not yet known. In this study, we show a higher expression of DEK mRNA in immature cells than in mature cells. Furthermore, a correlation between DEK expression and cell proliferation was demonstrated, suggesting that DEK plays a role in the proliferation of hematopoietic cells and raising the question of whether the DEK-CAN fusion protein might perturb regulation of proliferation in leukemic cells.


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