Haematologica
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Haematologica, Vol 91, Issue 2, 274-276
Copyright © 2006 by Ferrata Storti Foundation

Letter

Incidence of monoclonal B-cell disease in siblings of patients with multiple myeloma

M Engelhardt, G Ihorst, D Behringer, J Finke, and B Roth

We observed clustering of monoclonal B-cell disease in siblings being screened as allogeneic donors for patients with multiple myeloma (MM) scheduled for stem cell transplantation (SCT). Of 134 asymptomatic donors, the incidence of monoclonal B-cell disease was 8/84 in siblings and 1/50 in matched unrelated donors. From an analysis of five MM families scheduled for allogeneic SCT, monoclonal B-cell disease was detected in 8/27 siblings.




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Copyright © 2006 by the Ferrata Storti Foundation.