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Haematologica, Vol 91, Issue 3, 386-389
Copyright © 2006 by Ferrata Storti Foundation

Comparative Study

Stimulation of erythropoiesis by thalidomide in multiple myeloma patients: its influence on FasL, TRAIL and their receptors on erythroblasts

N Grzasko, A Dmoszynska, M Hus, and M Soroka-Wojtaszko

Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, Staszica 11, 20-080 Lublin, Poland.

The expression of proteins of the tumor necrosis factor (TNF) family on erythroblasts was measured during thalidomide treatment in 29 patients with multiple myeloma (MM). A clinical response was observed in 17 patients (58.6%) and haemoglobin concentration increased in 22 patients (75.9%). The expression of FasL, Fas, TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL-R1 on erythroblasts decreased significantly during thalidomide treatment. Additional in vitro studies revealed that the apoptosis of erythroblasts and the expression of FasL, TRAIL, TRAIL-R1 and TRAIL-R2 was lower in cultures with thalidomide than in control cultures. Altogether our results suggest that thalidomide may stimulate erythropoiesis in MM patients by decreasing the expression of TNF-like ligands/receptors on erythroblasts.


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W. Aerbajinai, J. Zhu, Z. Gao, K. Chin, and G. P. Rodgers
Thalidomide induces {gamma}-globin gene expression through increased reactive oxygen species mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis
Blood, October 15, 2007; 110(8): 2864 - 2871.
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