Haematologica, Vol 91, Issue 3, 397-400
Copyright © 2006 by Ferrata Storti Foundation
Prognostic value of donor cytotoxic T-lymphocyte precursor frequencies for acute graft-versus-host disease in hematopoietic stem cell transplantation from HLA-matched siblings: a single center experience in a cohort of 92 patients
F Sizzano,
P Magistroni,
F Locatelli,
A Busca,
M Falda,
P Affaticati,
G Mazzola,
AM Dall'omo,
and
A Amoroso
Department of Genetics, Biology and Biochemistry, University of Turin, Italy. fsizzano@molinette.piemonte.it
We investigated the prognostic value of cytotoxic T-lymphocyte precursor frequencies (CTL-p-f) for the development of graft-versus-host disease (GvHD) in a cohort of 92 recipients of a hematopoietic stem cell transplantation from HLA-matched sibling donors. CTL-p-f and clinical variables were correlated with acute GvHD and chronic GvHD in univariate and multivariate analyses. CTL-p-f resulted an independent risk factor for severe acute GvHD. Moreover, a trend towards a correlation between CTL-p-f and chronic GvHD was observed. In summary CTL-p-f may be considered as a functional assay useful for identifying patients at high risk of severe GVHD.
