Haematologica
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Haematologica, Vol 91, Issue 3, 425-426
Copyright © 2006 by Ferrata Storti Foundation

Comparative Study

Rituximab and DHAP followed by intensive therapy with autologous stem-cell transplantation as first-line therapy for mantle cell lymphoma

S de Guibert, A Jaccard, M Bernard, P Turlure, D Bordessoule, and T Lamy

We report on a series of 24 patients with newly diagnosed mantle cell lymphoma treated with four to six courses of DHAP-rituximab followed by autologous stem cell transplantation for patients <65 years. Three-year overall survival (OS) and event free survival (EFS) rates were 69% and 65% respectively, for the 24 patients. In intent-to-treat analysis, 3-year OS and EFS were 75% and 76% for the 17 patients < 65 years old. This treatment is quite feasible and compares favourably with other regimens.


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P. Dreger, M. Rieger, B. Seyfarth, M. Hensel, M. Kneba, A. D. Ho, N. Schmitz, and C. Pott
Rituximab-augmented myeloablation for first-line autologous stem cell transplantation for mantle cell lymphoma: effects on molecular response and clinical outcome
Haematologica, January 1, 2007; 92(1): 42 - 49.
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Copyright © 2006 by the Ferrata Storti Foundation.