Haematologica
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Haematologica, Vol 91, Issue 4, 530-533
Copyright © 2006 by Ferrata Storti Foundation

Journal Article

High-risk pregnancies in Diamond-Blackfan anemia: a survey of 64 pregnancies from the French and German registries

L Faivre, J Meerpohl, L Da Costa, I Marie, C Nouvel, A Gnekow, C Bender-Gotze, F Bauters, B Coiffier, PY Peaud, P Rispal, A Berrebi, C Berger, M Flesch, P Sagot, B Varet, C Niemeyer, G Tchernia, and T Leblanc

Centre de Genetique Medicale, Hopital d'Enfants, Dijon, France. laurence.faivre@chu-dijon.fr

We reviewed 64 pregnancies in 26 women with Diamond-Blackfan anemia (DBA) included in the French and German DBA registries. Complications were seen in 42 pregnancies (66%) and included abortion, pre-eclampsia, in utero fetal death, intrauterine growth retardation, retroplacental hematoma, pre-term delivery and fetal malformations. Of the 34 children (53%) born alive, 13 had DBA. No correlations were found between pregnancy outcome and features of either maternal or child DBA. Pregnancies in DBA-affected women are at high risk, especially for complications likely to be of vascular-placental origin. Careful monitoring with prevention of severe anemia and early introduction of aspirin is suggested.


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J. Flygare and S. Karlsson
Diamond-Blackfan anemia: erythropoiesis lost in translation
Blood, April 15, 2007; 109(8): 3152 - 3154.
[Abstract] [Full Text] [PDF]


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