Haematologica
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Haematologica, Vol 91, Issue 4, 574-576
Copyright © 2006 by Ferrata Storti Foundation

Letter

The effect of fludarabine on interferon-gamma production by lymphoid cells from healthy donors and patients with B-cell chronic lymphocytic leukemia

R Gamberale, P Fernandez-Calotti, J Sanchez-Avalos, MF Alberto, J Geffner, and M Giordano

Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently ill-defined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-gamma, a key cytokine in the pathogenesis of AHA.




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Copyright © 2006 by the Ferrata Storti Foundation.