Mutations of AML1 in non-M0 acute myeloid leukemia: six novel mutations and a high incidence of cooperative events in a South-east Asian population

Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Chulabhorn Cancer Centre, Bangkok, Thailand. sicaw@mahidol.ac.th

Point mutations of AML1 are uncommon and predominantly reported in a rare minimally differentiated acute myeloid leukemia (M0 AML). Few data exist regarding the frequency of AML1 mutations in non-M0 cases. We screened 284 consecutive adult Thai patients with de novo AML and found that 3.9% had AML1 mutations. The highest incidence occurred in M6. Six novel mutations were uniquely identified in non-M0 cases. Sixty-four percent of the non-M0 patients with AML1 mutations had coexisting genetic abnormalities including FLT3 mutation in 36%. Our study provides evidence to support the model of multiple co-operating events, which could also be critical in the development of leukemia in non-M0 AML patients with mutated AML1. The prognostic significance of these novel mutations remains to be determined.

This article has been cited by other articles:

				C. U. Auewarakul, A. Leecharendkeat, C. Tocharoentanaphol, O. Promsuwicha, N. Sritana, and W. Thongnoppakhun AML1 mutation and its coexistence with different transcription factor gene families in de novo acute myeloid leukemia: redundancy or synergism Haematologica, June 1, 2007; 92(6): 861 - 862. [Abstract] [Full Text] [PDF]