Haematologica
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Haematologica, Vol 91, Issue 5, 709-710
Copyright © 2006 by Ferrata Storti Foundation


Letter

Predicting erythroid response to recombinant erythropoietin plus granulocyte colony-stimulating factor therapy following a single subcutaneous bolus in patients with myelodysplasia

D Bowen, A Hyslop, N Keenan, M Groves, D Culligan, P Johnson, A Shaw, F Geddes, P Evans, J Porter, and I Cavill

We randomized 21 patients with low-risk myelodysplastic syndromes (MDS) to receive a single subcutaneous bolus of recombinant erythropoietin (epoietin) +/- granulocyte-colony stimulating factor (G-CSF), or placebo and monitored erythropoietic response over 7 days. In this small study, the reticulocyte response at day 7 was highly predictive of subsequent response to a therapeutic trial of epoietin + G-CSF.





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Copyright © 2006 by the Ferrata Storti Foundation.