Haematologica, Vol 91, Issue 5, 709-710
Copyright © 2006 by Ferrata Storti Foundation
Predicting erythroid response to recombinant erythropoietin plus granulocyte colony-stimulating factor therapy following a single subcutaneous bolus in patients with myelodysplasia
D Bowen,
A Hyslop,
N Keenan,
M Groves,
D Culligan,
P Johnson,
A Shaw,
F Geddes,
P Evans,
J Porter,
and
I Cavill
We randomized 21 patients with low-risk myelodysplastic syndromes (MDS) to receive a single subcutaneous bolus of recombinant erythropoietin (epoietin) +/- granulocyte-colony stimulating factor (G-CSF), or placebo and monitored erythropoietic response over 7 days. In this small study, the reticulocyte response at day 7 was highly predictive of subsequent response to a therapeutic trial of epoietin + G-CSF.