Haematologica
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Haematologica, Vol 91, Issue 5, 711-712
Copyright © 2006 by Ferrata Storti Foundation

Letter

The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines

F Timeus, N Crescenzio, E Ricotti, A Doria, D Bertin, G Saglio, and PA Tovo

We evaluated the effect of the human immunodeficiency virus (HIV) protease inhibitor saquinavir on the imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cell lines. Saquinavir, which is also a proteasome blocker, showed dose- and time-related anti-proliferative activity, particularly on the imatinib-resistant lines and a pro-apoptotic effect. Association with imatinib caused a significant increase of activity.




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Copyright © 2006 by the Ferrata Storti Foundation.