Haematologica
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Haematologica, Vol 91, Issue 5, 719-720
Copyright © 2006 by Ferrata Storti Foundation


Letter

Occurrence of the JAK2 V617F mutation in the WHO provisional entity: myelodysplastic/myeloproliferative disease, unclassifiable-refractory anemia with ringed sideroblasts associated with marked thrombocytosis

AF Remacha, JF Nomdedeu, G Puget, C Estivill, MP Sarda, C Canals, and A Aventin

The JAK2/V617F mutation has been noted in essential thrombocytemia. We investigated 19 cases with refractory anemia with ringed sideroblasts (RARS), including three RARS with thrombocytosis (RARS-T). Only the RARS-T patients showed this mutation. More cases need to be analyzed to determine the prevalence of the JAK2/V617F mutation in RARS-T.


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