Haematologica
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Haematologica, Vol 91, Issue 6, 805-808
Copyright © 2006 by Ferrata Storti Foundation

Journal Article

The effect of recombinant human intrinsic factor on the uptake of vitamin B12 in patients with evident vitamin B12 deficiency

AM Hvas, H Buhl, NB Laursen, B Hesse, L Berglund, and E Nexo

Department of Clinical Biochemistry, Skejby Hospital and Aarhus Hospital, Aarhus University Hospital, Aarhus, Denmark. am.hvas@dadlnet.dk

We report on the use of recombinant human intrinsic factor (rhIF) in a new vitamin B12 absorption test. Holotranscobalamin (holoTC) was measured before and 24 hours after intake of three 9-mg doses of vitamin B12 (B12) and again 24 hours after intake of the same dose of B12 together with rhIF (rhIF-B12). Nine patients with evident vitamin B12 deficiency had a significantly higher increase in holoTC after intake of rhIF-B12 than after intake of B12. Twenty-eight patients with suspected vitamin B12 deficiency showed no additional increase in holoTC after intake of rhIF-B12. We conclude that rhIF promotes B12 absorption among patients with evident vitamin B12 deficiency.




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Copyright © 2006 by the Ferrata Storti Foundation.