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Haematologica, Vol 91, Issue 6, 856-857
Copyright © 2006 by Ferrata Storti Foundation

Letter

The frequency of HLA class I alleles in Japanese patients with bone marrow failure

T Shichishima, H Noji, K Ikeda, K Akutsu, and Y Maruyama

The frequencies of the HLA-B*4002 and HLA-A*0206 alleles in patients with aplastic anemia (AA) (n=32; 21.9%) and paroxysmal nocturanl hemoglobinuria (PNH) (n=24; 22.9%), respectively, were significantly different from those in controls (n=371; 8.6%, p<0.002 and 7.7%, p<0.001, respectively), suggesting that each specific allele in AA or PNH may be related to the immunologic pathophysiology of these disorders.




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Copyright © 2006 by the Ferrata Storti Foundation.