Haematologica
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Haematologica, Vol 91, Issue 6_Suppl, ECR28-ECR28
Copyright © 2006 by Ferrata Storti Foundation

Journal Article

BCL10 gene amplification associated with strong nuclear BCL10 expression in a diffuse large B cell lymphoma with IGH-BCL2 fusion

H Ye, S Gesk, JI Martin-Subero, A Nader, MQ Du, and R Siebert

Division of Molecular Histopathology, Department of Pathology,University of Cambridge, Cambridge, United Kingdom.

Cytogenetic investigation of a nodal diffuse large B cell lymphoma carrying an IGH-BCL2-fusion revealed a homogeneously staining region at chromosome 1p21-22. Fluorescence in situ hybridisation (FISH) demonstrated heterogeneous BCL10 gene amplification in tumour cells. Immunohistochemistry showed heterogeneous over-expression of the protein in the nuclei of tumour cells, similar to that seen in MALT lymphoma cells with t(1;14)(p22;q32).




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Copyright © 2006 by the Ferrata Storti Foundation.