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Haematologica, Vol 91, Issue 7, 1001-1001
Copyright © 2006 by Ferrata Storti Foundation

Case Reports

Life-threatening motor neurotoxicity in association with bortezomib

S Gupta, A Pagliuca, S Devereux, GJ Mufti, and S Schey

Bortezomib has been licensed to be used in relapsed and refractory multiple myeloma. It is a promising agent for this incurable condition but our effort is to caution hematologists about the life-threatening neurotoxicity (grade 4) which was seen in two of six patients treated with this agent although the complication cannot definitely be attributed to bortezomib.


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