Haematologica, Vol 91, Issue 7, 980-982
Copyright © 2006 by Ferrata Storti Foundation
Prevalence, incidence and clinical outcome of hepatitis B virus and hepatitis C virus hepatitis in patients undergoing allogeneic hematopoietic stem cell transplantation between 2001 and 2004
D Francisci,
F Aversa,
V Coricelli,
A Carotti,
B Canovari,
F Falcinelli,
B Belfiori,
T Aloisi,
F Baldelli,
MF Martelli,
and
G Stagni
Division of Infectious Diseases, Department of Experimental Medicine and Biochemical Science, University of Perugia, Ospedale R. Silvestrini, Sant'Andrea delle Fratte, 06156, Perugia, Italy. francisd@unipg.it
The prevalence, incidence and clinical course of viral hepatitis were prospectively determined in consecutive recipients of T-cell depleted hematopoieic stem cell transplants (49 mismatched, 60 matched, mean age 38 years; range 11-65). The prevalence of hepatitis B virus (HBV) was 15.6% and that of hepatitis C virus was 3.7% (HCV). HBV reactivated in one patient. Another developed ex novo acute hepatitis B which progressed to chronic hepatitis. There were no new cases of hepatitis C or worsening of pre-transplant HCV infections. HBV and HBC did not affect the outcome of T-cell depleted hematopoieic stem cell transplantation. Surveillance is important given the risk of HCV and HBV infection and/or reactivation and the efficacy of the new anti-hepatitis drugs.
