Haematologica
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Haematologica, Vol 91, Issue 7, 998-1000
Copyright © 2006 by Ferrata Storti Foundation

Case Reports

Assessment of submicroscopic genetic lesions by single nucleotide polymorphism arrays in a child with acute myeloid leukemia and FLT3-internal tandem duplication

S Bungaro, M Raghavan, MG Dell'Oro, P Paolucci, BD Young, A Biondi, and G Cazzaniga

The same FLT3-internal tandem duplication (ITD) positive clone was detected at diagnosis and relapse, but not at birth, in a child with M1 acute myeloid leukemia. Single nucleotide polymorphism arrays demonstrated that chromosome 13 acquired uniparental disomy, in association with del(9q), represented a progressive event in the course of the disease, and it was responsible for the homozygous FLT3-ITD at relapse.




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Copyright © 2006 by the Ferrata Storti Foundation.