Osteonecrosis after allogeneic stem cell transplantation in childhood. A case-control study in Italy

Dept. of Hematology/Oncology, Bone Marrow Transplantation Section, G. Gaslini Children's Hospital, Largo G. Gaslini, 5, 16147 Genova, Italy. maurafaraci@ospedale-gaslini.ge.it

A case-control study was conducted among Italian children treated with a stem cell transplant (SCT). Cases (n = 43) were allogeneic recipients with osteonecrosis, and the controls (n = 129) were matched to the corresponding cases on the basis of survival, SCT center and date of transplant. Univariate analysis showed that older age at SCT (OR 1.39; 95% CI 1.24-1.57), total body irradiation (TBI) (OR 5.73; 95% CI 2.38-13.83), chronic graft-versus-host disease (GvHD) (OR 4.31; 95% CI 2.05-9.07), and duration of steroid treatment after SCT (OR 1.118; 95% CI 1.034-1.209) were statistically correlated with osteonecrosis. However, multivariate analysis revealed that the only factors that were significantly associated with osteonecrosis were older age at SCT (p = 0.0001), TBI (p = 0.001) and chronicGvHD (p = 0.001).

This article has been cited by other articles:

				N. S. Kadan-Lottick, I. Dinu, K. Wasilewski-Masker, S. Kaste, L. R. Meacham, A. Mahajan, M. Stovall, Y. Yasui, L. L. Robison, and C. A. Sklar Osteonecrosis in Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study J. Clin. Oncol., June 20, 2008; 26(18): 3038 - 3045. [Abstract] [Full Text] [PDF]