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Haematologica, Vol 91, Issue 8, 1109-1112
Copyright © 2006 by Ferrata Storti Foundation

Journal Article

Methodological approach to minimal residual disease detection by flow cytometry in adult B-lineage acute lymphoblastic leukemia

M Krampera, O Perbellini, C Vincenzi, F Zampieri, A Pasini, MT Scupoli, A Guarini, MS De Propris, E Coustan-Smith, D Campana, R Foa, and G Pizzolo

Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona. mauro.krampera@univr.it

A flow cytometric approach to minimal residual disease (MRD) monitoring useful in childhood B-lineage acute lymphoblastic leukemia (ALL) is discussed here in the context of ALL in adults. Of 64 leukemia samples analyzed, 95.3% had at least one abnormal phenotype (57.3% had two or more) as compared to physiologic B-cell precursors in adult bone marrow. The method was sensitive enough to detect one leukemic cell among 10,000 normal cells in 16/19 experiments (84.2%). Blast phenotypes were stable in culture and at relapse, and were useful for MRD monitoring in patients. Marker combinations for childhood ALL are also applicable to adult cases.


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M. J. Borowitz, M. Devidas, S. P. Hunger, W. P. Bowman, A. J. Carroll, W. L. Carroll, S. Linda, P. L. Martin, D. J. Pullen, D. Viswanatha, et al.
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