Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Costea, I
Right arrow Articles by Krajinovic, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Costea, I
Right arrow Articles by Krajinovic, M
Haematologica, Vol 91, Issue 8, 1113-1116
Copyright © 2006 by Ferrata Storti Foundation

Journal Article

Folate cycle gene variants and chemotherapy toxicity in pediatric patients with acute lymphoblastic leukemia

I Costea, A Moghrabi, C Laverdiere, A Graziani, and M Krajinovic

Research Center of the CHU Sainte-Justine, Montreal, Quebec, Canada.

The gene polymorphisms of the methotrexate (MTX) action pathway influence event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL). Here we assessed whether the gene variants associated with lower EFS also correlate with lower rates of episodes of toxicity. Homozygous individuals for cyclin D1 (CCND1) A870 allele and carriers of at least one methylenetetrahydrofolate reductase (MTHFR) T677 variant had a significantly lower frequency of weeks with high-grade hematologic and liver toxicity during consolidation and maintenance treatment, as based on the analysis of 186 pediatric ALL patients. This finding may have importance for MTX dose adjustment.


This article has been cited by other articles:


Home page
 BloodHome page
S. Dulucq, G. St-Onge, V. Gagne, M. Ansari, D. Sinnett, D. Labuda, A. Moghrabi, and M. Krajinovic
DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL
Blood, April 1, 2008; 111(7): 3692 - 3700.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Sharma, J. M. Hoskins, L. P. Rivory, M. Zucknick, R. London, C. Liddle, and S. J. Clarke
Thymidylate Synthase and Methylenetetrahydrofolate Reductase Gene Polymorphisms and Toxicity to Capecitabine in Advanced Colorectal Cancer Patients
Clin. Cancer Res., February 1, 2008; 14(3): 817 - 825.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 2006 by the Ferrata Storti Foundation.