Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mauro, F.
Right arrow Articles by Foa, R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mauro, F.
Right arrow Articles by Foa, R
Haematologica, Vol 91, Issue 8, 1117-1120
Copyright © 2006 by Ferrata Storti Foundation

Journal Article

Clinical features and outcome of familial chronic lymphocytic leukemia

FR Mauro, E Giammartini, M Gentile, I Sperduti, V Valle, A Pizzuti, A Guarini, D Giannarelli, and R Foa

Division of Hematology, Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Via Benevento 6, 00161 Rome, Italy. mauro@bce.uniroma1.it

The prognostic impact of the presence of a familial trait was analyzed in 1449 patient with chronic lymphocytic leukemia (CLL). A family history of hematologic malignancy (HM) was identified in 181 cases (12.5%) and recorded more frequently among female than male patients (HM: p < 0.05; CLL: p < 0.05). The relative was affected by CLL in 89 cases (6%). Familial and sporadic cases showed non-statistically different proportions of advanced stages (10.8 vs 7.1%) and patients requiring therapy (55 vs 60%) and a similar survival probability at 10 years (67 vs 66%). These data suggest that in CLL the presence of a familial trait does not imply an adverse prognosis.


This article has been cited by other articles:


Home page
 haematolHome page
A. W. Hauswirth and U. Jager
Impact of cytogenetic and molecular prognostic markers on the clinical management of chronic lymphocytic leukemia
Haematologica, January 1, 2008; 93(1): 14 - 19.
[Full Text] [PDF]

Home page
 ASH Education BookHome page
L. R. Goldin and S. L. Slager
Familial CLL: Genes and Environment
Hematology, January 1, 2007; 2007(1): 339 - 345.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 2006 by the Ferrata Storti Foundation.