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Haematologica, Vol 91, Issue 8, 1147-1148
Copyright © 2006 by Ferrata Storti Foundation

Letter

Mutations and promoter methylation status of NPM1 in myeloproliferative disorders

Y Oki, J Jelinek, M Beran, S Verstovsek, HM Kantarjian, and JP Issa

We determined mutations and promoter methylation status of NPM1 using pyrosequencing in 199 samples of myeloid neoplasia including myeloproliferative disorders (MPD). The mutations were present in 4% of chronic myelomonocytic leukemia, but not in other MPD or myelodysplastic syndromes. Promoter methylation was rare, and was found in only three samples of MPD.


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Copyright © 2006 by the Ferrata Storti Foundation.