Haematologica
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Haematologica, Vol 91, Issue 8_Suppl, ECR31-ECR31
Copyright © 2006 by Ferrata Storti Foundation

Case Reports

EBV-associated synovial lymphoma in a chronically inflamed joint in rheumatoid arthritis receiving prolonged methotrexate treatment

CS Chim, YY Pang, GC Ooi, MY Mok, and TW Shek

Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. jcschim@hku.hk

A patient with longstanding rheumatoid arthritis (RA) developed swelling in a chronically inflamed knee joint while receiving prolonged methotrexate treatment. Magnetic resonance imaging and positron-emission tomography showed soft tissue swelling with intense tracer uptake. Biopsy confirmed high-grade B-cell lymphoma. He developed complete remission with rituximab plus CEOP. The role of chronic inflammation and methotrexate in the pathogenesis of lymphoma in RA was discussed.




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Copyright © 2006 by the Ferrata Storti Foundation.