Haematologica
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Haematologica, Vol 91, Issue 9, 1241-1243
Copyright © 2006 by Ferrata Storti Foundation

Comparative Study

A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia

R Galanello, A Kattamis, A Piga, R Fischer, G Leoni, V Ladis, V Voi, U Lund, and F Tricta

Department of Biomedical Science and Biotechnology, University of Cagliari, Ospedale Microcitemico, Italy. renzo.galanello@mcweb.unica.it

We compared the safety and efficacy of alternating deferoxamine and deferiprone with that of deferoxamine monotherapy. Sixty transfusion-dependent thalassemia patients regularly treated with deferoxamine were randomized to continue deferoxamine alone or to receive an alternating therapy for one year. Both arms resulted in equivalent decreases of serum ferritin and liver iron concentration. There was no significant difference in the proportion of patients with adverse events in the two therapy groups although the nature of the adverse events differed according to the chelation regimen.


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