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Haematologica, Vol 91, Issue 9, 1252-1256
Copyright © 2006 by Ferrata Storti Foundation

Journal Article

DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma

MT Voso, D Gumiero, F D'Alo', F Guidi, G Mansueto, AL Di Febo, G Massini, M Martini, LM Larocca, S Hohaus, and G Leone

Istituti di Ematologia, Universita' Cattolica Sacro Cuore, Rome. mtvoso@rm.unicatt

We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).


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[Abstract] [Full Text] [PDF]


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