Haematologica
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Haematologica, Vol 91, Issue 9, 1273-1274
Copyright © 2006 by Ferrata Storti Foundation

Letter

The influence of lysophosphatidic acid on the immunophenotypic differentiation of human monocytes into dendritic cells

A Martino, E Volpe, and PM Baldini

Lysophosphatidic acid (LPA), a naturally occurring phospholipid, has been suggested to have an immunoregulatory role. We investigated the effect of LPA on differentiation of human monocytes into dendritic cells (DC). We found that LPA affects DC differentiation from monocytes by blocking the expression of CD1a molecules on their surface in a dose-dependent manner.




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Copyright © 2006 by the Ferrata Storti Foundation.