Haematologica
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Haematologica, Vol 91, Issue 9, 1277-1278
Copyright © 2006 by Ferrata Storti Foundation

Letter

ET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia

V Chaar, V Tarer, M Etienne-Julan, JP Diara, J Elion, and M Romana

The association of endothelin 1 (ET-1) and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphisms (G5665T and T8002C, VNTR and T-786C respectively) with the occurrence of acute chest syndrome and painful vaso-occlusive crises was evaluated in homozygous SS children. This retrospective study reveals that ET-1 T8002 and ecNOS C-786 alleles are associated with, respectively, an increased and a decreased risk of acute chest syndrome.




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Copyright © 2006 by the Ferrata Storti Foundation.