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Transient hypoxia and downregulation of circulating prohepcidin concentrations in healthy young men

Christian Benedict^*,, Andrew J. Ghio^°, Hartmut Gehring^#, Bernd Schultes^@, Achim Peters^{^}, Kerstin M. Oltmanns^*,

^* Department of Neuroendocrinology;
^° Clinical Research Branch, Human Studies Division, Office of Research and Development, U.S. Environmental Protection Agency, North Carolina 27599, USA;
^# Department of Anaesthesia;
^@ Obesity Centre, Spitalregion St. Gallen-Rorschach, CH-9400, Switzerland;
^{^} Department of Internal Medicine I;
Department of Psychiatry and Psychotherapy, University of Lübeck, D-23538, Germany

Correspondence: Christian Benedict, Department of Neuroendocrinology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Phone: international +49.4515004602. Fax: international +49.451.5003640. E-mail: benedict{at}kfg.uni-luebeck.de

To determine the impact of acute hypoxia on prohepcidin concentrations in humans, we measured concentrations of this peptide in serum collected during and after a transient period (30 min) of hypoxia and during normoxia. Prohepcidin concentrations were significantly lower 150 min after the end of hypoxia than after normoxia (p=0.028).

Key words: prohepcidin, hypoxia, iron.