Haematologica, Vol 92, Issue 1, 131-132 doi:10.3324/haematol.10455
Copyright © 2007 by Ferrata Storti Foundation
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Red Cell Disorders

Cardiac magnetic resonance imaging R2* assessments and analysis of historical parameters in patients with transfusion-dependent thalassemia

Athanassios Aessopos*,, Christina Fragodimitri°, Fotios Karabatsos°, Antonia Hatziliami°, Jacqueline Yousef°, Anastasios Giakoumis*, Aikaterini Dokou°, Efstathios D. Gotsis#, Vasilis Berdoukas°, Markissia Karagiorga°

* From the First Department of Medicine, University of Athens, Laiko General Hospital, Aghio Thoma 17, Athens Greece;
° The Thalassemia Unit, "Aghia Sophia" Children’s Hospital, Thivon Leivadias, Athens Greece;
# Euromedica Encephalos, Athens, Greece

Correspondence: Athanassios Aessopos, First Department of Internal Medicine, University of Athens Medical School, Laiko Hospital, Aghio Thoma 17, Athens Greece. E-mail: aaisopos{at}cc.uoa.gr

Recent advances in magnetic resonance imaging (MRI) techniques allow the assessment of iron overload in tissues1 especially the heart,2 in transfusion- dependent thalassemia patients. The R2* value (1/T2*) recorded in the intraventricular septum of the heart indirectly measures the degree of cardiac iron load. Applying this new technology we looked at a number of historical and biochemical parameters in order to determine their relationship to cardiac iron overload and the effect of cardiac iron on functional and structural changes of the heart in transfusion-dependent thalassemics.

Key words: thalassemia, iron overload, MRI, cardiac R2*.




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