Haematologica
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Haematologica, Vol 92, Issue 1, 143-144 doi:10.3324/haematol.10297
Copyright © 2007 by Ferrata Storti Foundation
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Multiple Myeloma

Extramedullary relapse of multiple myeloma associated with a shift in secretion from intact immunoglobulin to light chains

Mark A. Dawson*,, Sushrut Patil°, Andrew Spencer*,°

* Department of Haematology and Bone Marrow Transplantation, The Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia;
° Department of Clinical Haematology, Monash Hospital, Clayton Road, Clayton, Melbourne, Victoria 3168, Australi

Correspondence: Mark A. Dawson, The Alfred, Commercial Road, Prahran, Melbourne, Victoria, Australia 3181. Phone: international +61.39.2762000. Fax: international + 61.39.2763021. E-mail: dawsonm{at}ausdoctors.net

Biological therapies in multiple myeloma have heralded a new and exciting era for treatment to combat this disease. However the evolutionary pressures that these drugs place on the microenvironment has resulted in a change in the biological behaviour of this malignancy and novel manifestations of relapsed disease. This is illustrated in our series of three patients showing fulminant relapse of disease with plasmablastic features, an extramedullary predilection and a shift in secretion from intact immunoglobulin to free light chains only.




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M. J. Ayliffe, F. E. Davies, D. de Castro, and G. J. Morgan
Demonstration of changes in plasma cell subsets in multiple myeloma
Haematologica, August 1, 2007; 92(8): 1135 - 1138.
[Abstract] [Full Text] [PDF]


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Copyright © 2007 by the Ferrata Storti Foundation.