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Multiple Myeloma |
* Department of Haematology and Bone Marrow Transplantation, The Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia;
° Department of Clinical Haematology, Monash Hospital, Clayton Road, Clayton, Melbourne, Victoria 3168, Australi
Correspondence: Mark A. Dawson, The Alfred, Commercial Road, Prahran, Melbourne, Victoria, Australia 3181. Phone: international +61.39.2762000. Fax: international + 61.39.2763021. E-mail: dawsonm{at}ausdoctors.net
Biological therapies in multiple myeloma have heralded a new and exciting era for treatment to combat this disease. However the evolutionary pressures that these drugs place on the microenvironment has resulted in a change in the biological behaviour of this malignancy and novel manifestations of relapsed disease. This is illustrated in our series of three patients showing fulminant relapse of disease with plasmablastic features, an extramedullary predilection and a shift in secretion from intact immunoglobulin to free light chains only.
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M. J. Ayliffe, F. E. Davies, D. de Castro, and G. J. Morgan Demonstration of changes in plasma cell subsets in multiple myeloma Haematologica, August 1, 2007; 92(8): 1135 - 1138. [Abstract] [Full Text] [PDF] |
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