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Aids-related plasmablastic lymphoma of the oral cavity associated with an IgH/MYC translocation–treatment with autologous stem-cell transplantation in a patient with severe haemophilia-A

¹ Clinical Haematology/Bone Marrow Transplant Department, The Alfred, Melbourne, Victoria, Australia
² Ronald Sawers Haemophilia Centre and Thrombosis Clinic, The Alfred, Melbourne, Victoria, Australia
³ Department of Anatomical Pathology, The Alfred, Melbourne, Victoria, Australia
⁴ Department of Infectious diseases, The Alfred, Melbourne, Victoria, Australia
⁵ Department of Diagnostic Genetics, LabPlus, Auckland City Hospital, Auckland, New Zealand
⁶ Victorian Cancer Cytogenetics Service, St Vincent’s Hospital, Victoria, Australia

Corresponding Author: Dr Mark A. Dawson, The Alfred, Commercial Road, Prahran, Melbourne, Victoria, Australia 3181, dawsonm{at}ausdoctors.net, Tel: +61392762000 Fax: +61392763021

Plasmablastic lymphoma is an AIDS related lymphoma that continues to have a poor prognosis despite significant advances in the management of HIV and lymphoproliferative diseases. In part this has been due to limited insights into the biology of this disease and the molecular mechanisms of oncogenesis. To date molecular abnormalities have not been described in plasmablastic lymphoma, and its aggressive clinical behaviour has been difficult to understand. We describe the first reported cytogenetic abnormality in plasmablastic lymphoma, an IgH/MYC translocation. It is also the first description of autologous stem cell transplantation in a patient with severe haemophilia A.