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Successful treatment with T depleted autologous peripheral blood stem cell transplantation of refractory chronic autoimmune thrombocytopenic purpura

^* Divisione di Ematologia e Unità Trapianto e Servizio Immuno-trasfusionale Unità di Aferesi, Ospedale San Gerardo di Monza, Università degli Studi di Milano-Bicocca

Correspondence: Elena Elli, Divisione di Ematologia e Unità trapianto, Ospedale San Gerardo, Via Pergolesi 33, 20052 Monza, Italy. Phone: +39.039.2332392. Fax: +39.039.2333440. E-mail: elena.elli{at}libero.it

Autoimmune thrombocytopenia (AITP) is a disorder due to specific platelet auto-antibodies directed against platelet surface glycoproteins. AITP in adults is usually chronic, idiopathic and frequently refractory to conventional treatments. Myelo- and immuno- suppressive chemotherapy followed by autologous peripheral blood stem cell (PBSC) transplantation is an experimental approach for severe chronic refractory AITP. We report a case of a woman with AITP, refractory to the conventional therapy, submitted to T-cell-depleted autologous PBSC transplantation, which obtained long term stable response on platelet count. We deem that the positive outcome of our patient depends on T-cells depletion of the graft, which reduces autoreactive T clones.