Haematologica, Vol 92, Issue 10, 1429-1430 doi:10.3324/haematol.11314
Copyright © 2007 by Ferrata Storti Foundation
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Myelodysplastic Syndromes

Copper deficiency: an important consideration in the differential diagnosis of myelodysplastic syndrome

Thomas Fong*, Ravi Vij°,, Anitha Vijayan#, John DiPersio°, Morey Blinder*,@

* Divisions of Hematology and Oncology,
° Section of Bone Marrow Transplantation & Leukemia
# Division of Nephrology;
@ Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

Correspondence: Ravi Vij, M.D., Section of Bone Marrow Transplantation and Leukemia, Box 8007, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. Phone: international +1.314. 4548323. Fax: international +1.314.4547551. E-mail: rvij{at}im.wustl.edu

Copper deficiency is an etiology of anemia, neutropenia, and bone marrow dysplasia that may be under-recognized. We report 5 patients with clinical presentation consistent with MDS who were found to be deficient in copper and whose hematologic abnormalities resolved with copper supplementation. We recommend copper level assessment in patients suspected of having low-risk MDS, especially those with gastrointestinal disorders and neuropathy.

Key words: copper deficiency, myelodysplasia, diagnosis, therapy.




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