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Haematologica, Vol 92, Issue 10, 1431-1432 doi:10.3324/haematol.10874
Copyright © 2007 by Ferrata Storti Foundation
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Acute Myeloid Leukemia

Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines

Rafael Henriques Jácomo1, Raul Antonio Morais Melo2, Fernanda Ribeiro Souto2, Éderson Roberto de Mattos3, Claudia Teresa de Oliveira2, Evandro M. Fagundes4, Henrique Neves da Silva Bittencourt4, Rosane Isabel Bittencourt5, Teresa Cristina Bortolheiro6, Eduardo J.A. Paton7, Rodrigo Bendlin8, Sebastião Ismael9, Maria de Lourdes Chauffaille10, Dirceu Silva11, Katia Borgia B. Pagnano12, Raul Ribeiro13, Eduardo M. Rego1,

1 Department of Internal Medicine, Medical School of Ribeirao Preto, Brazil;
2 Molecular Biology Laboratory, HEMOPE, Brazil;
3 Bone Marrow Transplantation Unit, Hospital Amaral Carvalho, Brazil
4 Hematology Service, University of Minas Gerais, Brazil;
5 Hematology and Bone Marrow Transplantation Unit, HCPA, Brazil;
6 Hematology Service, Santa Casa de São Paulo, Brazil;
7 Fundação Pio XII de Barretos, Brazil;
8 Hematology Service; HCPR, Brazil;
9 Clínica de Hematologia de Ribeirão Preto, Brazil;
10 Department of Hematology and Hemotherapy, UNIFESP, Brazil;
11 Oncominas, Brazil;
12 Hemocentro, State University of Campinas, Brazil;
13 International Outreach Program, St. Jude Children’s Research Hospital, Memphis, TN, USA

Correspondence: Eduardo Magalhães Rego, Laboratório de Hematologia, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, São Paulo, 14048900, Brazil. Phone: international +55.16.36022888. Fax: international +55.16.36336695. E-mail: emrego{at}hcrp.fmrp.usp.br

We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent cause of failure (21.6%).

Key words: acute promyelocytic leukemia, ATRA, developing countries, Brazil.






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