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cAMP response element binding protein (CREB) overexpression CREB has been described as critical for leukemia progression

^* From the Department of Pediatrics, Laboratory of Pediatric Onco-Hematology, University of Padova, Padova, Italy
^° Department of Pediatrics, University of Torino, Torino, Ital
^# Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
^@ Department of Laboratory Medicine, Azienda Ospedaliera di Padova, Padova, Italy
^{^} Department of Pediatric, Hematology-Oncology, Ospedale dei Bambini "G. Di Cristina", Palermo, Italy

Correspondence: Giuseppe Basso, MD, University of Padua, Department of Pediatrics, Laboratory of Pediatric Onco-Hematology, via Giustiniani 3, 35128 Padua, Italy. Phone: international +39.049.8211466. Fax: international +39.049.8211462. E-mail: giuseppe.basso{at}unipd.it

CREB has been described as critical for leukemia progress. We investigated CREB expression in ALL and AML pediatric patients. CREB protein was significantly high (p<0.001) at diagnosis but not during remission. This study underlines the role of CREB in leukemia and suggests new insights into the transformation process.