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Failure of multiple antivirals to affect high HHV-6 DNAaemia resulting from viral chromosomal integration in case of severe aplastic anaemia

¹ Department of Paediatric Haematology and Oncology, Motol University Hospital, Prague, The Czech Republic;
² Institute of Haematology and Blood Transfusion, Prague, The Czech Republic;
³ Department of Paediatrics, Motol University Hospital, Prague, The Czech Republic

Correspondence: Petr Hubacek, M.D. Department of Paediatric Haematology and Oncology, Motol University Hospital, V Uvalu 84 CZ-150 06, Prague 5 – Motol, The Czech Republic. Phone: +420 224 432 026, Fax: +420 224 432 020. E-mail: Petr.Hubacek{at}Lfmotol.cuni.cz

We report a fifty-year-old woman presenting with severe aplastic anaemia (SAA) and prolonged high Human Herpesvirus 6 (HHV6) variant A DNAeamia detected by quantitative PCR. Multiple antiviral treatments failed to affect the HHV6 DNAemia and subsequent immunosuppressive treatment reached only partial improvement as judged by bone marrow examinations. The patient remained dependent on thrombocyte transfusions and G-CSF treatment. After one year of steady high HHV6 DNA load in blood, viral chromosomal integration was proved by demonstrating the viral DNA in hair follicles. This condition appeared to be unconnected with, and to have no effect, on the original SAA

Key words: human herpesvirus 6, severe aplastic anaemia, chromosomal integration.