Haematologica, Vol 92, Issue 11, 1574-1575 doi:10.3324/haematol.11493
Copyright © 2007 by Ferrata Storti Foundation
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Juvenile Myelomonocytic Leukemia

Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia

Andrica C.H. de Vries*, Ronald W. Stam*, Christian P. Kratz°, Martin Zenker#, Charlotte M. Niemeyer°, Marry M. van den Heuvel-Eibrink*,@, on behalf of the European Working Group on childhood MDS (EWOG-MDS)

* Department of Pediatric Oncology/Hematology, Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands
° Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University of Freiburg, Germany;
# Institute of Human Genetics, University of Erlangen-Nuremberg, Germany;
@ Dutch Childhood Oncology Group, The Hague, The Netherlands

Correspondence: Marry M. van den Heuvel-Eibrink, MD, PhD, Erasmus MC-Sophia Children’s Hospital, Dept. of Pediatric Hematology/Oncology, Room Sp 2568, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. Phone: international +31. 10.4636691. Fax: international +31.10.4636801. E-mail: m.vandenheuvel{at}erasmusmc.nl

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.

Key words: BRAF, juvenile myelomonocytic leukemia.




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