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The NQO1 C609T polymorphism is associated with risk of secondary malignant neoplasms after treatment for childhood acute lymphoblastic leukemia: a matched-pair analysis from the ALL-BFM study group

^* Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;
^° Department of Epidemiology, Social Medicine and Heatlh System Research, Hannover Medical School, Hannover, Germany;
^# Department of Pediatric Pulmonology and Neonatology, Hannover Medical School, Hannover, Germany;
^@ Department of Pediatrics; City Hospital; Oldenburg, Germany;
^{^} University Children’s Hospital, Kiel, Germany

Correspondence: Martin Stanulla, M.D., M.Sc., Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Phone: international +49.511.532 6712. Fax: international +49.5115329029. E-mail: stanulla.martin{at}mh-hannover.de

In a matched-pair study, we analyzed the association of a phenotypically relevant NQO1 polymorphism (C609T) with risk of secondary malignant neoplasms (SMN) after treatment for childhood acute lymphoblastic leukemia. Patients carrying a variant low-activity NQO1 allele had a significantly increased risk of developing a SMN. The observed effect was restricted to solid tumors.

Key words: acute lymphoblastic leukemia, childhood, secondary malignant neoplasms, NQO1, polymorphism.