Haematologica
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Haematologica, Vol 92, Issue 12, 1687-1690 doi:10.3324/haematol.11359
Copyright © 2007 by Ferrata Storti Foundation
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Aplastic Anemia

Antithymocyte globulin and cyclosporine for treatment of 44 children with hepatitis associated aplastic anemia

Yuko Osugi, Hiroshi Yagasaki, Masahiro Sako, Yoshiyuki Kosaka, Takashi Taga, Tsuyoshi Ito, Masuji Yamamoto, Akira Ohara, Takeyuki Sato, Junichi Mimaya, Ichiro Tsukimoto, Seiji Kojima, the Japan Childhood Aplastic Anemia Study Group

From Dept. of Pediatrics, Osaka General Medical Center, Osaka (YO, MS); Dept. of Pediatrics, Nagoya University Graduate School of Medicine,Nagoya (HY,SK); Dept. of Pediatrics, Kobe University Graduate School of Medicine,Kobe (YK); Dept. of Pediatrics, Shiga University of Medical Science, Otsu (TT); Dept. of Pediatrics, Toyohashi City Hospital Toyohashi (TI); Department of Pediatrics, Hyogo College of Medicine, Nishinomiya (MY); Dept. of Pediatrics, Toho University School of Medicine,Tokyo (AO, IT); Dept. of Pediatrics, Chiba University Graduate School of Medicine, Chiba (TS); Division of Hematology-Oncology, Shizuoka Children’s Hospital, Shizuoka (JM)

Correspondence: Seiji Kojima M.D., Ph.D., Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. E-mail: Kojimas{at}med.nagoya-u.ac.jp

We analyzed the outcomes of 44 children with hepatitis associated aplastic anemia (HAA) who received immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA). Fourteen (31.8%) patients achieved complete response and 17 (38.6%) achieved partial response, for an overall response rate of 70.4% after 6 months. Seven non-responders received bone marrow transplantation from an HLA-matched unrelated donor and 6 out of 7 are alive. The probability of overall survival at 10 years was 88.3±4.9%, which supports the role of IST with ATG and CsA as treatment of choice for children with HAA without an HLA identical sibling donor.

Key words: hepatitis associated aplastic anemia, antithymocyte globulin, cyclosporine, children.






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