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Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

¹ Dept. of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Denmark;
² Dept. of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark;
³ Dept. of Obstetrics, Gentofte Hospital, University of Copenhagen, Denmark;
⁴ Dept. of Medicine B, Rigshospitalet, University of Copenhagen, Denmark

Correspondence: Anne L. Mørkbak, Dept. of Clinical Biochemistry, Aarhus Sygehus, Nørrebrogade 44, K 8000 Aarhus, Denmark. Phone: international +45.89493065. Fax: international +45.89493060. E-mail: almor{at}as.aaa.dk

We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy.

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