Haematologica
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Haematologica, Vol 92, Issue 12, 1717-1718 doi:10.3324/haematol.12011
Copyright © 2007 by Ferrata Storti Foundation
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Myeloproliferative Disorders

JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis

Luz Martínez-Avilés*,^, Carles Besses°,, Alberto Álvarez-Larrán°, Francisco Cervantes#, Juan Carlos Hernández-Boluda@, Beatriz Bellosillo*,§

* Departments of Pathology and
° Clinical Hematology Hospital del Mar, IMAS, Barcelona;
# Department of Hematology, Hospital Clínic, University of Barcelona;
@ Department of Hematology, Hospital Clínic, Valencia;
^ Universitat Autònoma de Barcelona,
§ Universitat Pompeu Fabra, Spain

Correspondence: Carles Besses, MD, PhD, Department of Clinical Hematology, Hospital del Mar, Passeig Marítim 25-29 08003, Barcelona, Spain. Phone: international +34.9.32483341. Fax: international +34.9.32483131. E-mail: 92717{at}imas.imim.es

JAK2 exon 12 mutations were detected in 4 out of 20 polycythemia vera and idiopathic erythrocytosis V617F-negative patients and were only present in the myeloid lineage. Initial hematologic data of these patients differ from those of V617F-positive patients, but there is no difference in thrombotic development and myelofibrotic transformation.

Key words: JAK2 mutation, exon 12, V617F mutation, PV, erythrocytosis.


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Haematologica 2007 92: 1585-1589. [Full Text] [PDF]



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