Haematologica, Vol 92, Issue 12, 1727-1728 doi:10.3324/haematol.11531
Copyright © 2007 by Ferrata Storti Foundation
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Stem Cell Transplantation

Successful unrelated cord blood transplantation for a patient with CD40 ligand deficiency

Yoichiro Tsuji*,, Kohsuke Imai*, Yoichi Morinishi*, Kazuhiro Kogawa*, Masaaki Morino°, Shigeaki Nonoyama*

* Department of Pediatrics, National Defense Medical College, Saitama, Japan;
° Department of Pediatrics, Saitama Medical School, Saitama, Japan

Correspondence: Yoichiro Tsuji, M.D., Ph.D., Department of Pediatrics, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, 359-8513, Japan. Phone: international +81.4.29951611. Fax: international +81.4.29965204. E-mail: ytsuji{at}ndmc.ac.jp

We report a CD40 ligand deficiency (CD40LD) patient who was successfully treated with unrelated cord blood transplantation (URCBT). Conditioning regimen was busulfan and cyclophosphamide. The clinical course was uneventful and durable engraftment was achieved. This successful case encourages the use of URCB as an alternative donor source for CD40LD patients.

Key words: CD40 ligand deficiency, X-linked hyper-IgM syndrome, unrelated cord blood transplantation, class-switched memory B cell, TREC.