HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tsuji, Y. Articles by Nonoyama, S. Search for Related Content PubMed PubMed Citation Articles by Tsuji, Y. Articles by Nonoyama, S.

Successful unrelated cord blood transplantation for a patient with CD40 ligand deficiency

^* Department of Pediatrics, National Defense Medical College, Saitama, Japan;
^° Department of Pediatrics, Saitama Medical School, Saitama, Japan

Correspondence: Yoichiro Tsuji, M.D., Ph.D., Department of Pediatrics, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, 359-8513, Japan. Phone: international +81.4.29951611. Fax: international +81.4.29965204. E-mail: ytsuji{at}ndmc.ac.jp

We report a CD40 ligand deficiency (CD40LD) patient who was successfully treated with unrelated cord blood transplantation (URCBT). Conditioning regimen was busulfan and cyclophosphamide. The clinical course was uneventful and durable engraftment was achieved. This successful case encourages the use of URCB as an alternative donor source for CD40LD patients.

Key words: CD40 ligand deficiency, X-linked hyper-IgM syndrome, unrelated cord blood transplantation, class-switched memory B cell, TREC.