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The relationship between ABO groups and subgroups, factor VIII and von Willebrand factor

From the Departamento de Farmacologia, State University of Campinas (NCS, MLB-C); Hemocentro Unicamp, State University of Campinas, UNICAMP, Campinas, Brazil (JMA-B, MFL, VC)

Correspondence: Maria Lourdes Barjas-Castro, Hemocentro, UNICAMP/State University of Campinas–Unicamp, Rua Carlos Chagas, 480, PO Box–6198/CEP: 13083-970, Campinas–SP, Brazil. E-mail: maluz{at}unicamp.br

The aim of this study was to correlate ABO groups with plasma levels of factor VIII (FVIII), von Willebrand factor (VWF:Ag), and ristocetin cofactor (VWF:RCo). Serological and molecular tests defined blood groups from 114 donors (10 AA, 10 BB, 10 AB, 10 AO¹, 10 BO¹,16 O¹O¹, 20 A²O¹, 20 A²B, 4 A³O¹, 3 A^xO^1, and 1 B^elO¹). The levels of VWF:Ag, FVIII and VWF:RCo observed in rare subgroups (A³O¹, A^xO¹, B^elO¹) were similar to the values found in the O¹O¹ group. However, levels of these factors were significantly higher in A²O¹ donors than in O¹O¹ donors (VWF:Ag p=0.01; FVIII p=0.04; VWF:RCo p<0.001). Strong correlations were demonstrated between plasma levels of VWF:Ag and FVIII (R=0.77; p=0.001) and between VWF:Ag and VWF:RCo (R=0.75; p=0.001).

Key words: ABO, blood groups, factor VIII, von Willbrand factor.