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B-, T-, and NK-cell lineage involvement in JAK2^V617F-positive patients with idiopathic myelofibrosis

Department of Hematology, University of Florence, Florence, Italy

Correspondence: Alessandro Maria Vannucchi, Department of Hematology, University of Florence, 50134 Florence, Italy. E-mail: amvannucchi{at}unifi.it

An acquired JAK2^V617F mutation has been found in myeloid cells from most patients with chronic idiopathic myelofibrosis (IM), but whether it occurs in a common myelo-lymphoid, rather than a myeloid-restricted, progenitor cell is still debated. Using a sensitive ARMS assay for the quantitative assessment of JAK2^V617F cDNA, we detected the mutation in purified B, T and NK cells from about half of 12 patients studied. These results indicate that involvement of the lymphoid lineage in IM may be more frequent than previously supposed.

Key words: JAK2, idiopathic myelofibrosis, myeloproliferative disease, stem cells, .

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