Haematologica, Vol 92, Issue 2, 260-261 doi:10.3324/haematol.10753
Copyright © 2007 by Ferrata Storti Foundation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Antica, M.
Right arrow Articles by Batinic, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Antica, M.
Right arrow Articles by Batinic, D.

Acute Leukemia

A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia

Mariastefania Antica*,, Klara Dubravcic°, Igor Weber*, Ljubica Rasic°, Boris Labar°, Drago Batinic°

* Division of Molecular Biology, Ruder Boskoviç Institute
° Rebro Clinical Hospital, Zagreb, Croatia

Correspondence: Mariastefania Antica, Laboratory of Cellular and Molecular Immunology, Division Molecular Biology, Ruder Boskoviç Institute, Bijenicka 54, 10000 Zagreb, Croatia. Phone: international + 385.1.4561065. Fax: international + 385.1.4561177. E-mail: antica{at}rudjer.irb.hr

We examined whether phosphorylation of Aiolos in primary human lymphocytes is part of the malignant transformation in leukemia. By analyzing mutations at a restriction site we show here that impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro.

Key words: lymphocytes, leukemia, Aiolos.