Haematologica
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Haematologica, Vol 92, Issue 2, 262-263 doi:10.3324/haematol.10744
Copyright © 2007 by Ferrata Storti Foundation
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Acute Myeloid Leukemia

New types of MYST3-CBP and CBP-MYST3 fusion transcripts in t(8;16)(p11;p13) acute myeloid leukemias

Anne Murati*,°, José Adélaïde*, Benoît Quilichini#, Virginie Rémy*,°, Danielle Sainty°, Anne-Marie Stoppa@,, Philippe Bernard^, Sylviane Olschwang*,°, Daniel Birnbaum*, Max Chaffanet*, Marie-Joëlle Mozziconacci*,°

* Centre de Recherche en Cancérologie de Marseille, Département d’Oncologie Moléculaire, Institut Paoli-Calmettes et UMR599 Inserm, Marseille, France
° Département de BioPathologie, Institut Paoli-Calmettes, Marseille, France;
# Laboratoire de Cytogénétique, Hôpital de la Timone, Marseille, France
@ Département d’Hématologie, Institut Paoli-Calmettes, Marseille, France
^ Service d’Oncologie, Hôpital Sainte-Anne, Toulon, France

Correspondence: Marie-Joëlle Mozziconacci, Départements d’Oncologie Moléculaire et de BioPathologie, Institut Paoli-Calmettes, 232 Boulevard de Sainte-Marguerite, 13009 Marseille, France. Phone: international +33.4.91223447. Fax: international +33.4.91223544. E-mail: mozziconaccimj{at}marseille.fnclcc.fr

The t(8;16)(p11;p13) translocation, associated with poor prognosis acute monocytic leukemia, fuses MYST3 on chromosome region 8p11 to CBP on chromosome region 16p13. Two types of MYST3-CBP and CBP-MYST3 fusion transcripts have been identified in patients. We describe two new types of MYST3-CBP transcripts and a new primer set.

Key words: MYST3-CBP, CBP-MYST3, t(8;16), acute myeloid leukemia.




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K. Terui, T. Sato, S. Sasaki, K. Kudo, T. Kamio, and E. Ito
Two novel variants of MOZ-CBP fusion transcripts in spontaneously remitted infant leukemia with t(1;16;8)(p13;p13;p11), a new variant of t(8;16)(p11;p13)
Haematologica, October 1, 2008; 93(10): 1591 - 1593.
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